RAF Typhoon jets have operated alongside French warplanes in a combined operation against an hidden munitions depot in Syrian territory employed by the IS group, per a report from the UK's MoD.
The location, located using surveillance, was believed to be storing arms and explosives, the announcement noted, and was situated in mountainous terrain just north of Palmyra in Syria's central region.
"Our aircraft used Paveway IV guided bombs to hit a several approach shafts down to the depot... initial indications indicate the objective was successfully hit," the MoD said.
There was no evidence of any civilian casualties in the strike conducted Saturday night and each participating jet returned to base without incident, the MoD added.
The British jets were supported by a Voyager aerial refuelling aircraft.
IS - also known as the so-called Islamic State - established militant control over parts of both Syria and Iraq until 2019.
"This operation underscores our UK leadership, and resolve to stand shoulder to shoulder with allied nations, to eliminate any revival of Daesh and their dangerous and violent ideologies in the region," the British Defence Secretary John Healey stated.
British military aircraft have carried out overwatch operations over Syrian airspace to "forestall any efforts to regroup" of IS subsequent to its defeat at the Baghuz confrontation in 2019, the ministry said.
"I must thank the personnel of British forces involved in this mission for their professionalism and their bravery," he said. "They were part of thousands of British troops on duty over Christmas and New Year. This action, to remove dangerous terrorists who threaten our safety, demonstrates how our armed forces are prepared to act, all year round, keeping Britain secure at home and powerful internationally."
During December, the US military executed what it termed a "major assault" targeting Daesh sites in Syria, subsequent to an attack claimed the lives of two US troops and a local interpreter in the Palmyra area.
The United Nations estimates IS still maintains between 5,000 and 7,000 militants in Syria and Iraq.